Addenbrooke’s has been part of a £9 million study - one of largest and most successful academic collaborations to date. Organised by the Wellcome Trust Case Control Consortium, the study examined DNA samples from 17,000 people across the UK , bringing together 50 leading research groups and 200 scientists. The research has substantially increased the number of genes known to play a role in the development of some of our most common diseases.

Addenbrooke’s researchers have identified genes and areas of the genome that influence a person's susceptibility to Crohn’s disease and others that increase the chances of developing type 1 diabetes. In addition they have found a single region which influences both Crohn’s and diabetes. This is the first time a genetic link has been identified between the two diseases.

Dr Miles Parkes, Consultant Gastroenterologist at Addenbrooke's Hospital and the University of Cambridge said: "There is a lot of follow-up work required but the genetic findings themselves have already provided some major leads regarding possible new treatment options."

Professor John Todd, University of Cambridge said: "This new link is a possible new avenue to understand how they occur and advances in the treatment of Crohn’s disease may give us clues on how to treat type 1 diabetes."

 

Offsite link: BBC News - Serious diseases genes revealed

Offsite link: The Wellcome Trust Case Control Consortium (WTCCC)

 

 

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Last updated: 13 June 2007